The Kansas City Chiefs drafted Hall in the fifth-round of the 2000 NFL Draft. He made his NFL debut on September 24, 2000, as a kick/punt returner.
In 2003, Hall returned a kickoff or a punt for a touchdown four games in a row, which is an NFL record. The most memorable moment of the season came against the Denver Broncos in which he reversed direction twice to evade the entire special teams unit en route to a 93-yard punt return for a touchdown, his 7th in the 10-game stretch from the previous season, then went on to score 10 total touchdowns in 13 games.  In the playoffs that year against the Indianapolis Colts, Hall had another kickoff return for a touchdown, giving him five for the year, as well as a receiving touchdown. Hall was named to the 2004 Pro Bowl as a kick/punt returner for his second time.
Hall has established many nicknames in his career,  "X-factor", referring to how whenever he scored a touchdown he would cross his forearms to resemble an "X". Hall was also known as "The Human Joystick", referring to the agility he showed during returns.