Under head coach Nick Sirianni, the Philadelphia Eagles improved upon their 11–6 record in 2023, going 14–3. This was Philadelphia's fifth Super Bowl appearance.  Quarterback Jalen Hurts had an efficient season, with career highs in completion percentage, yards per attempt, passer rating, and only five interceptions. However, he only attempted 361 passes due to the high workload from Offensive Player of the Year and first-team All-Pro running back Saquon Barkley, who became the ninth player in league history with 2,000 rushing yards in a season.
Super Bowl LIX was also noted for its quality rookie play. Philadelphia rookie cornerback Cooper DeJean intercepted a pass from Mahomes and returned it for a touchdown, becoming the second rookie in Super Bowl history to achieve a pick-six, after Reggie Phillips in Super Bowl XX which was also played at the Superdome, as well as the first player in Super Bowl history to score a touchdown on his birthday.